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half life of psilocybin

How Long Do Shrooms (Psilocybin) Stay in Your System?

Mushrooms stay in your system for 24 hours or longer. Their effects last up to 6 hours.

How long routine drug tests can detect the presence of shrooms in your system also varies based on the type of test. For example:

Urine tests: Most people eliminate psilocybin within 24 hours. A urine drug test won’t detect their presence for much longer than this.
Hair tests: Psilocybin is detectable for as long as 90 days.
Blood tests: It takes psilocybin about 15 hours to leave your bloodstream. This is about how long it’s detectable in blood. However, blood tests are rarely used to detect shrooms. 
There are currently no reliable saliva drug tests for mushrooms.

Factors That Affect Detection Time

Factors affecting the time mushrooms stay in your system include:

Time Between Ingesting and Testing

The body eliminates mushrooms quickly. To detect mushrooms, testing must occur within 24 hours or less unless it’s a hair drug test. The sooner the test after taking mushrooms, the higher the likelihood they’ll be detected.

Half-Life

This is how long it takes for half of the mushrooms or any other drug to leave your system. The average half life of psilocybin is 3 hours.1

Mushroom Species

There are as many as 200 different species of psilocybin mushrooms. The higher the amount of hallucinogen present, the longer it remains detectable

 


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psychedelic mushrooms

Magic Mushrooms

For individuals in tune with drug culture, the aesthetic of bright, colorful mushrooms can be found on posters, t-shirts and on album covers of CDs and records. Shrooms, or magic mushrooms are a commonly recognized, natural hallucinogen. It is also considered to be one of the least dangerous narcotics that you can ingest. So what is it really?

What are Psychedelic Mushrooms?

Mushrooms containing the chemical psilocybin are considered to be ‘magic’ mushrooms. Ingesting these fungi produces intense hallucinations in the user. Historians hypothesize that psychedelic mushrooms were used in religious ceremonies and rituals around the world as far back as 6,000 years ago. Evidence of use has been found on cave rock art, and in sculptures in nearly every continent. Many users, even today, describe using mushrooms as a spiritual experience. In fact, in some countries, its use is still legal if it is used for religious ritual or for spirituality.

What is Psilocybin?

Psilocybin is a natural psychoactive, hallucinogenic substance that is found in hundreds of species of mushrooms. Though this magical formula has been used for hundreds of years, the compound was first isolated in 1958. Ingestion is the primary method of intake. Typically, the mushrooms are dried out and put on food to overcome the bitter taste, though they can also be brewed in tea or made into an oil. This chemical is converted into psilocin by the body, which has hallucinogenic effects that are similar to DMT or LSD. The intensity of the high is dependent on the species of mushroom and how much is ingested. As with any substance, the user’s physiology plays a role. It has a low toxicity and typically does not cause harm to the body.

Abusing Mushrooms

Psilocybin is a non-addictive substance. This means that despite it having powerful effects on the body and mind, there is no craving or withdrawal. Despite there being no actual cravings, many users do enjoy regular recreational use. While it is very rare, it is possible to overdose on magic mushrooms. Psychologically and physically, it is considered to be one of the safest drugs to use. There can be uncomfortable side effects, though, they are not devastating.

To identify the rare but possible risks of overdose, you should be aware of the following:

Panic Attacks
Paranoia
Psychosis
Seizures
Vomiting
Being in a high stress mindset, or in a volatile place that you are not comfortable in can all impact whether or not you experience difficulties while using mushrooms.

 


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lung cancer treatments

Common Symptoms of Lung Cancer

There are several lung-related symptoms of lung cancer that appear after the cancer has been growing for some time, including:

Coughing. Coughing that doesn’t go away or gets worse and is not related to a viral or bacterial infection affecting your lungs.
Shortness of breath. Feeling out of breath, tightness in the chest, feeling like you can’t breathe, or feeling you can’t get enough air. There are non-cancerous conditions that can also cause this symptom. Either way you should have a doctor check your lungs.
Coughing up bloody mucus. Coughing up blood-tinged or rust-colored phlegm or mucus.
Chest pain. Pain that gets worse with laughing, coughing, or deep breathing.
Wheezing. Wheezing is that high-pitched whistling sound that happens when exhaling.
Lung infections that won't clear. Repeated infections such as pneumonia or bronchitis, or a lung infection that won't go away will likely be evaluated further by your doctor for another cause. 
Hoarseness. If your voice becomes hoarse for no apparent reason you should have this evaluated by a doctor.
What's Next if You Receive a Lung Cancer Diagnosis?
If the symptoms you noticed and reported to your doctor were caused by lung cancer, you're likely to visit with an oncologist who specializes in lung cancer treatments. They will determine the type of lung cancer, stage, and other factors that allows them to create a personalized treatment plan. If you're in the Colorado Front Range, the Rocky Mountain Cancer Centers team is here to guide you through the process every step of the way. 

 


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Lung Cancer Symptoms

16 Unexpected Lung Cancer Symptoms You Should Know About

Lung cancer doesn't always show obvious signs or symptoms until it's become more advanced. A cough that won't go away or shortness of breath without another cause are some of the more common symptoms you hear about. But, did you know there are several other surprising signs and symptoms that can indicate lung cancer?

What Causes Lung Cancer and Who Can Get It?
It's probably no surprise that smoking is one of the main causes of lung cancer.

Smoking causes 80% of the lung cancer deaths in women and 90% in men.
Men that smoke are 23 times more likely to get lung cancer.         
Female smokers are 13 times more prone to develop lung cancer.
? Related Read: The Leading Cause of Lung Cancer Deaths? Yes, It’s Smoking

But non-smokers get lung cancer too — risk factors include extensive exposure to radon gas and worked-related exposure to carcinogens such as fumes. Non-smokers who are exposed to second-hand smoke have a 20-30% greater risk for developing lung cancer.

Lung cancer is most common in people over 65. However, younger adults can and do develop lung cancer, but less than 2% of patients are below 35. Learn more about the risk factors for developing lung cancer. 

 


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Lung cancer

What is lung cancer?

Lung cancer starts when abnormal cells grow and multiply in an uncontrolled way. Cancer that begins in the lungs is called primary lung cancer. If cancer begins in another part of the body and spreads to the lungs it is know as secondary or metastatic cancer in the lung.

Lung cancer is the leading cause of cancer death and the fifth most common cancer diagnosed in Australia excluding non-melanoma cancers. It is responsible for almost one in five cancer deaths in Australia. 

It is estimated that more than 14,700 people were diagnosed with lung cancer in 2023. The average age at diagnosis is 72 years old. 

Lung cancer is the fifth most commonly diagnosed cancer in Australia, and it is estimated that one in 20 people will be diagnosed by the time they are 85.

There are two main types of lung cancer: 

Non-small cell lung cancer (NSCLC) 

Non-small cell lung cancer is the most common type of lung cancer, accounting for around 85% of cases. There are sub-types of non-small cell lung cancer. The most common are: 

adenocarcinoma - begins in mucus-producing cells and makes up about 40% of lung cancers. While this type of lung cancer is most commonly diagnosed in current or former smokers, it is also the most common lung cancer in non-smokers. 
squamous cell (epidermoid) carcinoma - commonly develops in the larger airways of the lung. 
large cell undifferentiated carcinoma - can appear in any part of the lung and are not clearly squamous cell or adenocarcinoma. 
Lung cancer signs and symptoms
Symptoms of lung cancer may include: 

·         shortness of breath

·         changes to the voice such as hoarseness

·         chest pain

·         coughing or spitting up blood

·         a new cough that does not go away

·         chest infection that lasts more than three weeks or keeps coming back

·         enlarged fingertips

·         loss of appetite

·         unexplained weight loss

·         tiredness.

 


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depression Treatment

epressive disorder (also known as depression) is a common mental disorder. It involves a depressed mood or loss of pleasure or interest in activities for long periods of time.

Depression is different from regular mood changes and feelings about everyday life. It can affect all aspects of life, including relationships with family, friends and community. It can result from or lead to problems at school and at work.

Depression can happen to anyone. People who have lived through abuse, severe losses or other stressful events are more likely to develop depression. Women are more likely to have Depression Treatment than men.

An estimated 3.8% of the population experience depression, including 5% of adults (4% among men and 6% among women), and 5.7% of adults older than 60 years. Approximately 280 million people in the world have depression (1). Depression is about 50% more common among women than among men. Worldwide, more than 10% of pregnant women and women who have just given birth experience depression (2). More than 700 000 people die due to suicide every year. Suicide is the fourth leading cause of death in 15–29-year-olds.

Although there are known, effective treatments for mental disorders, more than 75% of people in low- and middle-income countries receive no treatment (3). Barriers to effective care include a lack of investment in mental health care, lack of trained health-care providers and social stigma associated with mental disorders.

Symptoms and patterns

During a depressive episode, a person experiences a depressed mood (feeling sad, irritable, empty). They may feel a loss of pleasure or interest in activities.

A depressive episode is different from regular mood fluctuations. They last most of the day, nearly every day, for at least two weeks.

Other symptoms are also present, which may include:

poor concentration
feelings of excessive guilt or low self-worth
hopelessness about the future
thoughts about dying or suicide
disrupted sleep
changes in appetite or weight
feeling very tired or low in energy.
Depression can cause difficulties in all aspects of life, including in the community and at home, work and school.

A depressive episode can be categorized as mild, moderate, or severe depending on the number and severity of symptoms, as well as the impact on the individual’s functioning. 

There are different patterns of depressive episodes including:

single episode depressive disorder, meaning the person’s first and only episode;
recurrent depressive disorder, meaning the person has a history of at least two depressive episodes; and
bipolar disorder, meaning that depressive episodes alternate with periods of manic symptoms, which include euphoria or irritability, increased activity or energy, and other symptoms such as increased talkativeness, racing thoughts, increased self-esteem, decreased need for sleep, distractibility, and impulsive reckless behaviour.  


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Prognosis for Lung Cancer

Prognosis for Lung Cancer

Lung cancer has a poor prognosis. On average, people with untreated advanced non–small cell lung cancer survive 6 months. Even with treatment, people with extensive small cell lung cancer or advanced non–small cell lung cancer do especially poorly, with a 5-year survival rate of less than 1%. Early diagnosis improves survival. People with early non–small cell lung cancer have a 5-year survival of 50 to 70%. However, people who are treated definitively for an earlier stage lung cancer and survive but continue to smoke are at high risk of developing another lung cancer.

Survivors must have regular checkups, including periodic chest x-rays and CT scans to ensure that the cancer has not returned. Usually, if the cancer returns, it occurs within the first 2 years. However, frequent monitoring is recommended for 5 years after lung cancer treatment, and then people are monitored yearly for the rest of their lives.

Because many people die of lung cancer, planning for terminal care is usually necessary. Advances in end-of-life care, particularly the recognition that anxiety and pain are common in people with incurable lung cancer and that these symptoms can be relieved by appropriate drugs, have led to an increasing number of people being able to die comfortably at home, with or without hospice services

 


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lung cancer symptoms

lung cancer symptoms

The symptoms of lung cancer depend on its type, its location, and the way it spreads within the lungs, to areas near the lungs, or elsewhere in the body. Some people have no symptoms at the time of diagnosis.

One of the more common symptoms is a persistent cough or, in people who have a chronic cough, a change in the character of the cough. Some people cough up blood or sputum streaked with blood (hemoptysis). Rarely, lung cancer grows into an underlying blood vessel and causes severe bleeding.

Additional nonspecific symptoms of lung cancer include loss of appetite, weight loss, fatigue, chest pain, and weakness.

Complications of lung cancer
Lung cancer may narrow the airway, causing wheezing. If a tumor blocks an airway, part of the lung that the airway supplies may collapse, a condition called atelectasis. Other consequences of a blocked airway are shortness of breath and pneumonia, which may result in coughing, fever, and chest pain.

If the tumor grows into the chest wall, it may cause persistent, unrelenting chest pain. Fluid containing cancerous cells can accumulate in the space between the lung and the chest wall (a condition referred to as malignant pleural effusion). Large amounts of fluid can lead to shortness of breath and chest pain. If the cancer spreads throughout the lungs, the levels of oxygen in the blood become low, causing shortness of breath and eventually enlargement of the right side of the heart and possible heart failure (a disorder called cor pulmonale).

Lung cancer may grow into certain nerves in the neck, causing a droopy eyelid, small pupil, and reduced perspiration on one side of the face—together these symptoms are called Horner syndrome.

Cancers at the top of the lung may grow into the nerves that supply the arm, making the arm or shoulder painful, numb, and weak. Tumors in this location are often called Pancoast tumors. When the tumor grows into nerves in the center of the chest, the nerve to the voice box may become damaged, making the voice hoarse, and the nerve to the diaphragm may become damaged, causing shortness of breath and low blood oxygen levels.

Lung cancer may grow into or near the esophagus, leading to difficulty swallowing or pain with swallowing.

Lung cancer may grow into the heart or in the midchest (mediastinal) region, causing abnormal heart rhythms, blockage of blood flow into the heart, or fluid in the sac surrounding the heart (pericardial sac).

The cancer may grow into or compress one of the large veins in the chest (the superior vena cava). This condition is called superior vena cava syndrome. Blockage of the superior vena cava causes blood to back up in other veins of the upper body. The veins in the chest wall enlarge. The face, neck, and upper chest wall—including the breasts—can swell, causing pain, and become flushed. The condition can also cause shortness of breath, headache, distorted vision, dizziness, and drowsiness. These symptoms usually worsen when the person bends forward or lies down.

Lung cancer may also spread through the bloodstream to other parts of the body, most commonly the liver, brain, adrenal glands, spinal cord, or bones. The spread of lung cancer may occur early in the course of disease, especially with small cell lung cancer. Symptoms—such as headache, confusion, seizures, and bone pain—may develop before any lung problems become evident, making an early diagnosis more complicated.

 


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What is Psilocybin Mushrooms?

What is Psilocybin Mushrooms?

While there are many types of mushrooms in the world, a few varieties contain a chemical called psilocybin, which can have hallucinogenic effects when ingested.1 Psilocybin mushrooms are native to Central and North America, in countries that include Mexico and the United States.1

While these mushrooms have been used for centuries by indigenous populations for religious and social rites, they became widely used as part of the counterculture movement of the 1960s until they were made illegal in 1968.2

Psilocybin mushrooms may also be called:1,2 

Hallucinogenic mushrooms
Magic mushrooms
Shrooms
Psychedelic mushrooms
Though some proponents urge further investigation into psilocybin for potential therapeutic benefits, the Drug Enforcement Administration (DEA) currently lists mushrooms as a Schedule I substance.1,3 Schedule I drugs have a high risk for abuse, no known medical benefits, and are not approved for any use, even under the care of a doctor.1

Psilocybin Mushrooms Effects

Psilocybin interacts with our brain’s serotonergic neurotransmitter system in a way thought to underlie the various physiological and hallucinogenic effects associated with the drug.2,3  Many factors can influence the effects of the drug, including:2

The potency or amount of mushrooms ingested.
Prior experiences with mushrooms.
Your personality.
The setting you are in when you take the drug.
Your mental state at the time of ingestion.
Psilocybin Mushroom Overdose and Withdrawal
Since mushrooms are grown naturally and not synthesized in a lab, it is difficult to monitor and regulate the doغیر مجاز می باشدe. It is estimated that a lethal dose would be 1,000 times that of an effective dose, making it highly unlikely for someone to overdose on mushrooms unless an underlying health condition existed.

With no significant physiological dependence associated with the drug, withdrawal is not likely, although it may take a day or two to feel normal after ingesting mushrooms. You may feel lingering effects of the mushrooms, like feeling tired or having difficulty discerning fantasy or dreams from reality.

 


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Microdosing Psilocybin

Microdosing has become increasingly popular over the last decade. A microdosing regimen typically entails the ingestion of a psychedelic substance at a sub-hallucinogenic dose, usually 5–10% of a standard dose. Psilocybin and lysergic acid diethylamide (LSD) are the most common psychedelics used for microdosing and users commonly follow the Fadiman protocol, which suggests that one should dose every third day to achieve optimal effects (Fadiman, 2011; Hutten et al., 2019). Anecdotal reports and observational studies suggest that microdosing can have antidepressant and anxiolytic effects (Anderson et al., 2019; Cameron et al., 2020; Fadiman and Korb, 2019; Johnstad, 2018; Kaertner et al., 2021; Lea et al., 2020; Petranker et al., 2020; Polito and Stevenson, 2019; Webb et al., 2019). Users with mental health conditions, such as anxiety and obsessive-compulsive disorder (OCD), report microdosing as a form of self-medication (Hutten et al., 2019; Johnstad, 2018).

However, the available evidence regarding the efficacy of Microdosing Psilocybin for mental health remains inconsistent. Three of the four existing experimental studies on humans found no evidence for the alleged antidepressant and anxiolytic effects (Bershad et al., 2019; Family et al., 2020; Szigeti et al., 2021). The fourth, Hutten et al. (2020), found that 20 μg LSD increased positive mood but also anxiety. These inconsistencies may well be related to differences in study designs. The observational studies investigated the effects of microdosing longitudinally, either by gathering cross-sectional data from a subpopulation of individuals who regularly practice microdosing, or via prospective observational design that gathered data from before, during, and after a predetermined microdosing period (Bornemann, 2020). These studies did not control for psychedelic substances or doغیر مجاز می باشدes. In contrast, three of the four experimental studies focused only on the effects of LSD microdosing compared with placebo and investigated the acute effect of varying doses (Bershad et al.: 6.5, 13 and 26 μg; Family et al.: 5, 10 and 20 μg; Hutten et al.: 5, 10 and 20 μg). Participants of the fourth self-blinded experimental study self-administered psychedelic microdoses of their choice (i.e. primarily LSD and psilocybin), over 4 weeks. The authors assessed both acute and post-acute effects and controlled for varying dose quantities (Szigeti et al., 2021). The two experimental studies investigating the effect of microdosing on rats also reveal mixed results. Horsley et al. (2018) found a modest anxiogenic effect in the elevated-plus maze when the rats were tested 48 h after the third microdose of both psilocin and ketamine. In contrast, Cameron et al. (2019) found no effects of a 2-month dimethyltryptamine (DMT) microdosing protocol on anxiety but did find reduced immobility in the forced swim paradigm, which is considered an antidepressant-like effect, and less freezing behaviour following fear extinction training, which may reflect enhanced fear extinction.

 


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