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Magic mushrooms and mental health

The effects of psilocybin and psilocin on the brain may have therapeutic potential for treating mental health conditions such as depression, anxiety, addiction, and post-traumatic stress disorder (PTSD). Psilocybin mushrooms may help people break free from rigid and negative patterns of thinking and behavior by increasing creativity, flexibility, and openness. Psilocybin may also help people access and process traumatic memories and emotions by reducing the fear response and increasing empathy and compassion. Several studies have shown that psilocybin can produce lasting improvements in mood, well-being, and quality of life in patients with depression 3 , anxiety 4 , addiction 5 , and PTSD. Psilocybin may also induce mystical or spiritual experiences that can have profound and positive effects on a person's worldview, values, and meaning in life.

Addiction and dangers of magic mushrooms

Magic mushrooms and psilocybin are non-addictive and have very little risk of physical harm or toxicity. However, Magic Mushroom can cause unpleasant or challenging effects such as anxiety, paranoia, confusion or psychosis. These effects are influenced by the dose, personality, conditions of use, expectations and psychological state of the individual.

Therefore, it is better to use Magic Mushroom with caution and under professional guidance in a safe and comfortable environment. Research on the effects of psilocybin on the body continues, but no serious physical risks have been reported in the use of magic mushroom, and there is no possibility of overdose with this mushroom. For more information on this topic, is it possible to overdose with magic mushrooms? read the

Magic mushroom and treatment of depression

In a 2012 study, David Knott, a neuroscientist at Imperial College London, found that in depressed people, connections between brain circuits in certain areas were stronger. In an interview with Psychology Today, Professor Nott says: "People who suffer from depressive thinking, their brains are over-connected, and they experience obsessive and overwhelming negative thoughts and feelings of self-criticism. Professor Nutt explains that the psilocybin mushroom can provide powerful relief by loosening these connections and creating new connections.

There are many doctors and psychiatrists who are not so sure about legalizing magic mushrooms for treatment. They believe that it may take more time to reveal the side effects of Magic Mushroom and it is still too early to comment on this. Especially now that all the treatments are done under the control and supervision of special people and it is not known what fatal side effects will be caused by using it individually.

"Right now, there aren't many options for using magic mushrooms," says Dr. Shimi Kang, a Vancouver psychiatrist who was the principal investigator of Canada's first study of magic mushrooms and their effects on treatment-resistant depression. One option is special access, where the patient and doctor must prove they've tried every other treatment and get special approval. This is a private job, so it's out of pocket. A second option is to go through research studies or Clinical Trials Using Psilocybine at one of the Toronto academies we just heard about. These are free, however, there is no guarantee that you can easily participate in these schemes and there are quite strict criteria. In addition, we have all seen how people in situations are under very controlled and monitored conditions.

"I say don't do it," he says of legalizing magic mushrooms for everyone. These plants are very powerful. Yes, magic mushrooms are natural! We know that when used well, they can have profound health effects, we see that, but when used incorrectly, in the wrong dose at the wrong time, without taking into account the interactions of appropriate medical supervision for other diseases or drugs, it can cause complications. have a very serious negative side. It is true, however, that these are generally safe when consumed appropriately by appropriately experienced and trained individuals who know how to make these trips."

According to him, as a psychiatrist with 20 years of experience, the use of Magic Mushroom legally requires more and deeper studies. It should not be repeated with a quick decision the problems that have been created with other psychedelics.

Extemporaneous compounding of MDMA and psilocybin products

Pharmacists should consider the guidelines on compounding of medicines. See the Pharmacy Board of Australia codes, guidelines and policies- external site. The guidelines include detailed guidance on when it is appropriate for a medicine to be compounded and the requirements to be complied with when compounding medicines.

Pharmacists should be aware:

MDMA and psilocybin products are controlled drugs under the Commonwealth Criminal Code. This means MDMA and psilocybin cannot be possessed, manufactured or supplied unless authorised by law.

The exemptions under the Therapeutic Goods Act 1989 that permit pharmacists to engage in extemporaneous compounding do not amount to an authorisation under the Criminal Code.

Compounding by pharmacists may be unlawful in some states and territories. If the pharmacy licensing arrangements in the relevant state or territory do not authorise the compounding of MDMA and psilocybin products (e.g., if they do not authorise the compounding of Schedule 8 or Schedule 9 substances) and there is no separate authority that applies, the compounding of such goods will contravene the Commonwealth Criminal Code. Hence, pharmacists should seek advice from their state or territory health department prior to engaging in extemporaneous compounding of MDMA or psilocybin containing products.

Prescribers and pharmacists should also consider individual legal and professional responsibilities when a compounded medicine is prescribed and subsequently compounded and dispensed.

It is expected that pharmacists will use Natural Pharmaceutical Grade Psychedelics ingredients that comply with quality standards.

Quality standards

There are currently no pharmacopeial monographs for MDMA or psilocybin. The TGA will develop quality standards based on the active ingredients and finished products currently being supplied to clinical trials. These standards (Therapeutic Goods Orders, TGO) will ensure consistent quality of the medicines supplied to Australian patients. The requirements will apply to both compounded and commercially manufactured medicines.

GMP licensed pharmacy 

TGA GMP licensed compounders will need a new authorisation on their licence to compound MDMA or psilocybin. These licences will be conditioned to require reporting on the quantities these goods manufactured and held at the premises, as required under Australia’s international obligations. 

Any site applying for a new TGA GMP licence will similarly require the specific authorisations under that licence to manufacture MDMA or psilocybin medicines and have conditions to report on the quantity of goods held and supplied.

VANCOUVER, British Columbia, Nov. 16, 2022 (GLOBE NEWSWIRE) -- PharmAla Biotech Holdings Inc. (“PharmAla”)(CSE: MDMA), a biotechnology company focused on the research, development, and manufacturing of MDXX class molecules, including MDMA, and Mindset Pharma Inc. (CSE: MSET) (FSE: 9DF) (OTCQB: MSSTF) ("Mindset"), a drug discovery company developing novel, optimized, next-generation psychedelic and non-psychedelic medications to treat neuropsychiatric and neurological disorders with unmet medical needs, today announced that they have entered into an exclusive sales agreement. Under the sales agreement, PharmAla will be the exclusive global reseller of Mindset’s cGMP (i.e. pharmaceutical grade) psilocybin to appropriately licensed clinical researchers.

“In addition to forging new ground in next generation psychedelic drug discovery, Mindset has also developed a patent-pending, highly scalable psilocybin synthesis technology. A غیر مجاز می باشدt-effective supply of first generation psychedelic therapeutics is essential to the overall development of the medical psychedelic space, and Mindset is eager to help meet this increased demand for pharmaceutical grade psilocybin from researchers,” said James Lanthier, CEO of Mindset. “We have chosen PharmAla as a partner because of their track record in working with clinical researchers, and existing sales infrastructure to sell Pharmaceutical Grade Psychedelics compounds. It’s also yet another concrete example of Mindset commercializing and creating value from its portfolio of innovations.”

Mindset has recently completed production of a large batch of cGMP psilocybin at the U.S. site of an international contract development and manufacturing company (“CDMO”) pursuant to the annual DEA quota on psilocybin.

“While we have until now focused exclusively on MDMA and its analogues, we’ve heard time and again that our clinical partners want access to other research materials. We see significant synergies in this partnership with Mindset; our sales infrastructure, as well as our Canadian pharmaceutical value chain, can create revenue opportunities for both companies,” said Nick Kadysh, CEO of PharmAla. “With the culmination of this agreement, we’re the first and only organization that is able to offer the clinical research community two of the most high-quality and in-demand APIs in Psychedelics: PharmAla’s GMP LaNeo™ MDMA, and Mindset’s cGMP Psilocybin.”

Magic mushroom or psilocybin mushroom grows in different tropical regions of the world and is considered a hallucinogenic drug. You might ask, what is a mushroom? What are the side effects of using Magic Mushroom? In this article, we will talk about mushroom drugs in general, or hallucinogenic mushrooms. Stay with us until the end of the article to get answers to your questions.

What is magic mushroom?

Magic mushroom or psilocybin, which is more commonly known as magic mushroom or mushroom. These mushrooms are hallucinogens that contain the chemical psilocybin. Mushroom drugs are very popular among people because of their psychoactive effects. Psilocybin was first discovered in 1958 by Dr. Albert Hoffman. There are different types of these magic mushroom drugs, each of which has a different dose of psilocybin. Sometimes they are confused with poisonous mushrooms, so it is necessary to know the types of mushrooms.

Some mushrooms are cultivated in indoor environments or they are wild. Hallucinogenic mushrooms contain two types of psilocybin and psilocin compounds. Psilocybin is the main psychoactive compound in these mushrooms, and psilocybin is found in a smaller amount in them, but it is stronger than psilocybin. By eating hallucinogenic mushrooms, psilocybin is converted into psilocin after being metabolized.

Types of magic mushrooms or hallucinogenic mushrooms

There are about 200 species of psychedelic mushrooms around the world, which have different names and are usually classified according to their biological genus. Among the most common ones are Psilocybin, Gymnopilus, Panaeolus and Copelandia, which are found all over the world. In general, hallucinogenic or psychedelic mushrooms are mushrooms with dark spores and gills that grow in the forests of subtropical and tropical regions.

How to use Magic Mushroom ingredients

If you have a question, how are mushrooms consumed? We will discuss it in this section. How to consume drugs Mushrooms are fresh or dried, or they can be brewed as tea or consumed with cigarettes or marijuana. These drug mushrooms can also be used in foods or cooked alone and then consumed. Psilocybin mushroom can be dried and made into a powder and put into a capsule and swallowed. Of course, the injection of this mushroom has also been seen in some cases, but this method is very rare. For this reason, injecting psilocybin powder is very dangerous and can be fatal.

PTSD Treatment

Learn more about PTSD treatment at Options Behavioral Health System in Indianapolis, IN

Experiencing a traumatic event can cause a great deal of pain. For some individuals that have experienced a traumatic event, over time, the associated fear and anxiety eventually dissipate. For others, however, the fear and anxiety remain constant, or even worsen, as time passes. In such instances, it is possible that these individuals are suffering from posttraumatic stress disorder, or PTSD.

Posttraumatic stress disorder is a mental illness that is caused by being exposed to a traumatic event. A traumatic event can be anything that invokes feelings of helplessness and fear, or that may cause an individual to believe that his or her life, or the life of a loved one, is in danger. Examples of traumatic events include domestic violence, car accidents, natural disasters, rape, and military combat.

At Options Behavioral Health, we understand the complexities of PTSD and the degree of anguish that this disorder can cause. We also know that facing the emotions that result from experiencing a traumatic event may seem unbearable. However, we are proud to have helped many people at our center learn to manage the symptoms of PTSD by offering state-of-the-art treatment that is provided by an experienced team of professionals. Options Behavioral Health is an 84-bed, free-standing psychiatric hospital devoted to providing a full continuum of care for adolescents, ages 12 to 18, adults, and older adults who are battling the symptoms of any number of mental health concerns, including posttraumatic stress disorder. At our hospital, individuals can learn the tools they need to successfully achieve a brighter future.

Non-small cell lung cancer symptoms

Non-small cell lung cancers (NSCLC) may grow slowly over a period of time before symptoms develop. Common non-small cell lung cancer symptoms include:

Persistent coughing, particularly without any known cause
A cough that produces blood or red-colored phlegm (hemoptysis)
Chest pain or painful breathing
Difficulty breathing or shortness of breath
Fatigue or feeling unusually weak or tired
Hoarseness or wheezing
Frequent upper-respiratory infections, like bronchitis or pneumonia
Bone pain
Other areas of the body may be affected by either the spread or development of NSCLC tumors.

Neurological changes: Lung cancer may spread (metastasize) to the brain. This may cause headaches or even seizures. Numbness or weakness in the arms and legs may occur if a large tumor begins to press against a nerve.

Lumps: In advanced stages, the cancer may spread throughout the lymph nodes. Sometimes, tumors near the skin surface may appear as lumps.

Horner syndrome: Tumors may possibly cause nerve damage. Horner syndrome is a particular set of symptoms associated with nerve damage. The symptoms often affect one side of the face, causing a droopy eyelid and a reduction in the size of the pupil (the dark center of the eye).

Paraneoplastic syndromes: Cancer cells may make chemicals that trigger other reactions, which are collectively referred to as paraneoplastic syndromes. Symptoms may include high blood calcium levels (hypercalcemia), excess bone growth or blood clots.

Small cell lung cancer symptoms

Most of the signs associated with small cell lung cancer (SCLC) are not present until the cancer has progressed. Typically, small cell lung cancer symptoms continue to evolve and worsen as the disease spreads to distant organs.

Early symptoms of small cell lung cancer:

Persistent cough
Chest pain that gets worse with deep breathing, laughing or coughing
Hoarseness
Unexplained loss of appetite and weight
Coughing up blood or rust-colored phlegm
Shortness of breath
Feeling weak and/or tired
Bronchitis, pneumonia or other infections that keep recurring
Wheezing
Symptoms of advanced-stage SCLC:

Bone pain
Headaches, dizziness or limbs that become weak or numb
Jaundice
Lumps in the neck or collarbone region
 symptoms of small cell lung cancer

additional details about GMP grade natural psilocybin:

Safety and purity: GMP standards ensure that natural psilocybin is produced under conditions that minimize the risk of contamination or impurities. This includes measures to prevent microbial, chemical, and physical contamination. Stringent quality control processes are implemented to verify the purity and safety of the final product.

Consistency and potency: GMP grade natural psilocybin aims to ensure consistent potency and quality from batch to batch. This involves precise control of manufacturing processes, accurate measurement of psilocybin content, and adherence to strict specifications for the final product. By maintaining consistent quality, patients and researchers can rely on the expected potency and effects of the psilocybin.

Compliance with regulations: GMP grade natural psilocybin aligns with regulatory requirements and guidelines set forth by authorities in the jurisdiction where it is produced or used. This includes compliance with relevant laws, regulations, and guidelines related to the production, testing, labeling, and distribution of pharmaceutical substances.

Traceability and accountability: GMP standards emphasize traceability and accountability throughout the supply chain. This involves maintaining detailed records of the entire production process, including the sourcing of raw materials, manufacturing steps, quality control tests, and distribution. This traceability allows for transparency and facilitates product recall or investigation if necessary.

Quality management systems: GMP grade natural psilocybin manufacturers implement robust quality management systems to ensure consistent adherence to GMP principles. This includes establishing quality control procedures, conducting regular internal audits, and implementing corrective and preventive actions to address any deviations or non-compliance.

It's important to note that GMP compliance primarily applies to the production and manufacturing of psilocybin as a pharmaceutical substance. The use of psilocybin itself, whether in therapeutic or research settings, may be subject to separate regulations and oversight.

Additionally, the current legal status of psilocybin varies across countries and regions. While some jurisdictions have decriminalized or legalized psilocybin for medical or research purposes, it remains a Schedule I controlled substance in many places. It is essential to understand and comply with the legal frameworks and regulations specific to your location.

In this post, we’ll discuss the most common types of psychedelic mushrooms. Often referred to as ‘magic mushrooms,’ many people consume an excess amount of these fungi. That’s one of the reasons we wanted to publish this article. People for whom mushroom use has become a problem will benefit greatly from a little knowledge. First, you need to know hat psilocybin is the active ingredient in many, though not all, magic mushroom varities. Psilocybin is a naturally-occurring psychedelic compound produced by more than 200 species of mushrooms.  Many of these mushroom species include other psychoactive substances that also act as hallucinogens. We’ll summarize the effects of different types of magic mushrooms in just a bit. However, most of these effects have a powerful effect on the way the user perceives reality. 

The Three Most Common Types of Psychedelic Mushrooms
The names of magic mushrooms may seem unfamiliar, but most users have encountered one or more of these common varieties.

1. Psilocybe cubensis 
Of all the different types of magic mushrooms, Psilocybe cubensis is one that most users are familiar with. This kind of mushroom has a cap that is usually reddish-brown, with a white to yellowish stem. Mushroom hunters tend to find it in damp, humid climates, often growing on the feces of grazing animals. 

2. Psilocybe semilanceata
Also known as the liberty cap, the psilocybe semilanceata is another common psilocybin mushroom. P. semilanceata tends to thrive in areas like moist, grassy fields that are used for cattle. This is a relatively small mushhroom, ranging in color from light yellow to brown and has a pointed cap.

Psilocybe baeocystis
Also known as bluebell or bottle cap is yet another and has a dark brown wavy cap and yellowish or brownish stem when fresh. It can be found in fields and also on rotting logs, peat or mulch. 

Psychotherapy for depression treatment

If there is no underlying medical cause for your symptoms of depression, talk therapy can be an extremely effective treatment. What you learn in therapy gives you skills and insight to feel better and help prevent depression from coming back.

There are many types of therapy available. Three of the more common methods used in depression treatment include cognitive behavioral therapy, interpersonal therapy, and psychodynamic therapy. Often, a blended approach is used.

Individual or group therapy?
When you hear the word “therapy” you might automatically think of one-on-one sessions with a therapist. However, group therapy can be very useful in depression treatment as well. Both group and individual therapy sessions usually last about an hour. What are the benefits of each? In individual therapy, you are building a strong relationship with one person, and may feel more comfortable sharing some sensitive information with one person than with a group. You also get individualized attention.

In group therapy, listening to peers going through the same struggles can validate your experiences and help build self-esteem. Often group members are at different points in their depression, so you might get tips from both someone in the trenches and someone who has worked through a challenging problem. As well as offering inspiration and ideas, attending group therapy can also help increase your social activities and network.

Ruling out medical causes of depression
If you suspect that you may be depressed, and lifestyle changes haven't worked, make an appointment to see your primary care doctor for a thorough checkup. If your depression is the result of medical causes, therapy and antidepressants will do little to help. The depression won't lift until the underlying health problem is identified and treated.

Your doctor will check for medical conditions that mimic depression, and also make sure you are not taking medications that can cause depression as a side effect. Many medical conditions and medications can cause symptoms of depression, including sadness, fatigue, and the loss of pleasure. Hypothyroidism, or underactive thyroid, is a particularly common mood buster, especially in women. Older adults, or anyone who takes many different medications each day, are at risk for drug interactions that cause symptoms of depression. The more medications you are taking, the greater the risk for drug interactions.